Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer

Bardia, Aditya; M. Tolaney, Sara; Punie, Kevin; Loirat, Delphine; Oliveira, Mafalda; Kalinsky, Kevin; Zelnak, Amelia; Aftimos, Philippe; Dalenc, Florence; Sardesai, Sagar; Hamilton, Erika; Sharma, Priyanka; Recalde, Sabela; Ciruelos Gil, Eva; Traina, T; O’Shaughnessy, Joyce; Cortés, Javier; Tsai, Mu‐Hung; T. Vahdat, Linda; Dièras, Véronique; A. Carey, Lisa; S. Rugo, Hope; M. Goldenberg, David; Hong, Q.; Olivo, Martin; M. Itri, Loretta; A. Hurvitz, Sara

doi:10.1016/j.annonc.2021.06.002

Public

Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer

Published in Annals of Oncology • Jun 8, 2021

Authors:

Aditya Bardia

Sara M. Tolaney

Kevin Punie

Abstract

•The majority of patients (80%) with mTNBC in the ASCENT study with available data had high/medium tumor Trop-2 expression.•Survival outcomes and ORRs were numerically higher in SG- versus TPC-treated patients with high/medium Trop-2 expression.•Benefit of SG in patients with high/medium Trop-2 expr...

Subject

Medicine

Internal medicine

Oncology

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