Highly-specific memory B cells generation after the 2 nd dose of BNT162b2 vaccine compensate for the decline of serum antibodies and absence of mucosal IgA

Piano Mortari, Eva; Russo, Cristina; Vinci, M.; Terreri, Sara; Fernandez Salinas, Ane; Piccioni, Livia; Alteri, Claudia; Colagrossi, Luna; Coltella, Luana; Ranno, Stefania; Linardos, Giulia; Agosta, Marilena; Albano, Christian; Agrati, Chiara; Castilletti, Concetta; Meschi, Silvia; Romania, Paolo; Roscilli, Giuseppe; Pavoni, Emiliano; Camisa, Vincenzo; Santoro, Annapaola; Brugaletta, Rita; Magnavita, Nicola; Ruggiero, Alessandra; Cotugno, Nicola; Amodio, Donato; Luisa Ciofi degli Atti, Marta; Giorgio, Daniela; Russo, Nicoletta; Salvatori, Guglielmo; Corsetti, Tiziana; Locatelli, Franco; Federico Perno, Carlo; Zaffina, Salvatore; Carsetti, Rita

doi:10.1101/2021.06.08.21258284

Public

Highly-specific memory B cells generation after the 2 nd dose of BNT162b2 vaccine compensate for the decline of serum antibodies and absence of mucosal IgA

Published in medRxiv • Jun 9, 2021

Authors:

Eva Piano Mortari

Cristina Russo

M. Vinci

Abstract

Abstract Specific memory B cells and antibodies are reliable read-out of vaccine efficacy. We analyzed these biomarkers after one and two doses of BNT162b2 vaccine. The second dose significantly increases the level of highly-specific memory B cells and antibodies. Two months after the second dose, s...

Subject

Antibody

Memory B cell

Immunology

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