Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

Kustin, Talia; Harel, Noam; Finkel, Uriah; Perchik, Shay; Harari, Sheri; Tahor, Maayan; Caspi, Itamar; Levy, Rachel; Leshchinsky, Michael; Ken Dror, Shifra; Bergerzon, Galit; Gadban, Hala; Gadban, Faten; Eliassian, Eti; Shimron, Orit; Saleh, Loulou; Ben‐Zvi, Haim; Keren Taraday, Elena; Amichay, Doron; Ben-Dor, Anat; Sagas, Dana; Strauss, Merav; Shemer Avni, Yonat; Huppert, Amit; Kepten, Eldad; D. Balicer, Ran; Netzer, Doron; Ben‐Shachar, Shay; Stern, Adi

doi:10.1038/s41591-021-01413-7

Public

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

Published in Nature Medicine • Jun 14, 2021

Authors:

Talia Kustin

Noam Harel

Uriah Finkel

Abstract

The BNT162b2 mRNA vaccine is highly effective against SARS-CoV-2. However, apprehension exists that variants of concern (VOCs) may evade vaccine protection, due to evidence of reduced neutralization of the VOCs B.1.1.7 and B.1.351 by vaccine sera in laboratory assays. We performed a matched cohort s...

Subject

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

2019-20 coronavirus outbreak

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