Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland

Vennekens, Annelies; Laporte, Emma; Hermans, Florian; Cox, Benoit; Modave, Elodie; Janiszewski, Adrian; Nys, Charlotte; Kobayashi, Hiroto; Malengier‐Devlies, Bert; Chappell, Joel; Matthys, Patrick; Garcia, Marie‐Isabelle; Pasque, Vincent; Lambrechts, Diether; Vankelecom, Hugo

doi:10.1073/pnas.2100052118

Public

Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland

Published in Proceedings of the National Academy of Sciences • Jun 14, 2021

Authors:

Annelies Vennekens

Emma Laporte

Florian Hermans

Abstract

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon target...

Subject

Stem cell

Pituitary gland

Cell biology

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