The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Ding, Xingchen; Wang, Liangliang; Zhang, Xuedong; Xu, Junlong; Li, Peifeng; Liang, Hua; Zhang, Xianbin; Xie, Li; Zhou, Zihan; Yang, Jia; R. Weichselbaum, Ralph; Yu, Jinming; Hu, Man

doi:10.1186/s13045-021-01102-5

Public

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Published in Journal of Hematology & Oncology • Jun 12, 2021

Authors:

Xingchen Ding

Liangliang Wang

Xuedong Zhang

Abstract

Abstract Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown. Here, we explored the relationship between HIF-1α and PD-L1 ex...

Subject

Glioma

Cancer research

Hypoxia (environmental)

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