Sotorasib for Lung Cancers with <i>KRAS</i> p.G12C Mutation

Skoulidis, Ferdinandos; T. Li, Bob; K. Dy, Grace; Price, Timothy; S. Falchook, Gerald; Wolf, Jürgen; Italiano, Antoîne; Schüler, Martin; Borghaei, Hossein; Barlési, Fabrice; Kato, Terufumi; Curioni‐Fontecedro, Alessandra; G. Sacher, Adrian; I. Spira, Alexander; S. Ramalingam, Suresh; Takahashi, Toshiaki; Besse, Benjamin; Anderson, Abraham; Ang, Agnes; Tran, Qui; Mather, Omar; Henary, Haby; Ngarmchamnanrith, Gataree; Friberg, Gregory; Velcheti, Vamsidhar; Govindan, Ramaswamy

doi:10.1056/nejmoa2103695

Public

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

Published in New England Journal of Medicine • Jun 4, 2021

Authors:

Ferdinandos Skoulidis

Bob T. Li

Grace K. Dy

Abstract

BACKGROUND: p.G12C-mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in a subgroup of patients with non-small-cell lung cancer (NSCLC). METHODS: p.G12C-mutated advanced NSCLC previously treated with standard therapies. The primary end point...

Subject

KRAS

Medicine

Lung cancer

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