Metabolic features of cancer cells impact immunosurveillance

Joseph, Adrien; Juncheng, Pan; Mondini, Michele; Labaied, Nizar; Loi, Mauro; Adam, Julien; Lafarge, Antoine; Astesana, Valentina; Obrist, Florine; Klein, Christophe; Bloy, Norma; Stoll, Gautier; Signolle, Nicolas; Genestie, Catherine; Damotte, Diane; Alifano, Marco; Léary, Alexandra; Pautier, Patricia; Morice, Philippe; Gouy, Sébastien; Deutsch, Éric; Chargari, Cyrus; Dieu‐Nosjean, Marie‐Caroline; Cremer, Isabelle; Michels, Judith; Kroemer, Guido; Castedo, Maria

doi:10.1136/jitc-2021-002362

Public

Metabolic features of cancer cells impact immunosurveillance

Published in Journal for ImmunoTherapy of Cancer • Jun 1, 2021

Authors:

Adrien Joseph

Pan Juncheng

Michele Mondini

Abstract

Background Tumors rewire their metabolism to achieve robust anabolism and resistance against therapeutic interventions like cisplatin treatment. For example, a prolonged exposure to cisplatin causes downregulation of pyridoxal kinase (PDXK), the enzyme that generates the active vitamin B6, and upreg...

Subject

Immunosurveillance

Immune system

Cancer research

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