Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

Zocher, Sara; W. Overall, Rupert; Lesche, Mathias; Dahl, Andreas; Kempermann, Gerd

doi:10.1038/s41467-021-23993-1

Public

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

Published in Nature Communications • Jun 23, 2021

Authors:

Sara Zocher

Rupert W. Overall

Mathias Lesche

Abstract

The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-wide DNA methylation sequencing, we here show t...

Subject

DNA methylation

Epigenetics

Environmental enrichment

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