Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

Miles, David; Gligorov, Joseph; André, Fabrice; Cameron, David; Schneeweiß, Andreas; H. Barrios, Carlos; Xu, Binghe; Wardley, Andrew; Kaen, Diego; Andrade, Livia; Vf, Semiglazov; Reinisch, Mattea; Patel, Shilpen; Patre, Monika; Morales, L.; Lal Patel, Sipahee; Kaul, Manika; Barata, Teresa; O’Shaughnessy, Joyce; Zhang, Q.; Xu, Binghe; Shao, Zhimin; Wang, Xiangyu; Geng, Cuizhi; Yan, Xingchen; Tong, Zhongsheng; Shen, Kunwei; Yin, Yongmei; Sun, Tao; Chih‐Hsin Yang, James; Feng, J; Yan, Min; Wang, Yan; Liu, Qiang; Zhang, S.; De Laurentiis, Michelino; Santoro, Armando; Guarneri, Valentina; Colleoni, Marco; Natoli, Clara; Cortesi, Laura; De Placido, Sabino; Gianni, Lorenzo; Ferraù, Francesco; Livi, Lorenzo; Zambelli, Alberto; Del Mastro, Lucia; Tonini, Giuseppe; Montemurro, Filippo; Bianchi, Giulia; Pedersini, R.; A. Del Prete, Salvatore; Allegrini, Giacomo; Naso, Giuseppe; Vici, Patrizia; Loirat, D.; Mailliez, Audrey; Priou, Franck; Trédan, Olivier; Dalenc, F.; Perrin, Christophe; Gligorov, Joseph; David, Morales-Pancorbo; Dohollou, Nadine; Teixeira, Luís; Brocard, Fabien; Arnaud, Antoine; Delaloge, Suzette; Spano, Jean‐Philippe; Mansi, Luigi; Andrade, Livia; Damian, Fernanda; Luiz Pedrini, José; M. Aleixo, Sandra; Hegg, Roberto; Junior, R.; Reinisch, Mattea; Schmidt, Marcus; Wenzel, C.; Grischke, E.‐M.; Schneeweiß, Andreas; Just, Marianne; Harbeck, Nadia; Schumacher, Claudia; Peters, Ubong; Fischer, Dorothea; Forstbauer, Helmut; Liersch, Rüdiger; Warner, Ellen; Bouganim, Nathaniel; T. Doyle, C.; Price Hiller, Julie; Vandenberg, Ted; Pavic, Michel; Robinson, Andrew; Roldan Urgoiti, Gloria; Califaretti, Nadia; Alacacıoğlu, Ahmet; Gumus, M.; Yalçın, Bülent; Cicin, I.; Köse, Fatih; Uygun, Kazım; Ma, Kaplan; Çubukçu, Erdem; Wardley, Andrew; Harries, Mark; Miles, David; Doval, Dinesh; Gupta, Sameer; Mohapatra, Prerana; Chatterjee, Sanjoy; Ghadyalpatil, Nikhil; Singhal, Manish; Nag, Shubhadeep; Agarwal, Amit; Wolf, Ido; Gal Yam, Einav; Yerushalmi, Rinat; Peretz, T; Fried, Georgeta; Ben Baruch, Noa; A. Katz, Deborah; Hamilton, E.P.; Kayali, Fadi; Brufsky, Adam; L. Telli, Melinda; S. Wright, Gail; H. Oyola, Raul; J. Rakowski, Thomas; L. Graff, Stephanie; Tjulandin, Sergei; Vf, Semiglazov; M. Aparicio, Ana; Ruíz Borrego, Manuel; de la Cruz‐Merino, Luis; G. Martínez, Joaquín; López, Escarlata; Yamashita, Toshinari; Ohtani, Shoichiro; Inoue, Kenichi; Ito, Y.; Niikura, Naoki; Nakayama, Takahiro; Sagara, Yasuaki; Yanagita, Y.; Kamada, Yuhei; Kaneko, K.; Kaen, Diego; Nervo, Adrián; Eniu, Alexandru; Schenker, Michael; Priester, Peter; Melichar, Bohuslav; Zimovjanová, Martina; Sormova, P.; Šufliarský, Jozef; Kakalejcik, M.; Belbaraka, R.; Errihani, Hassan; Than, D.; Thinh Pham, Duc; Aravantinos, Gerasimos; Papadimitriou, Christos; Koumakis, G.; N. Papandreou, Christos; Podolski, Paula; Tabane, Keo

doi:10.1016/j.annonc.2021.05.801

Public

Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

Published in Annals of Oncology • Jul 1, 2021

Authors:

David Miles

Joseph Gligorov

Fabrice André

Abstract

BACKGROUND: In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in the intention-to-treat (ITT) and programmed d...

Subject

Atezolizumab

Medicine

Internal medicine

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