In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

E. Chen, Rita; S. Winkler, Emma; Brett Case, James; D. Aziati, Ishmael; L. Bricker, Traci; Joshi, Astha; L. Darling, Tamarand; Ying, Baoling; M. Errico, John; Shrihari, Swathi; A. VanBlargan, Laura; Xie, Xuping; Gilchuk, Pavlo; J. Zost, Seth; Droit, Lindsay; Liu, Zhuoming; Stumpf, Spencer; Wang, David; A. Handley, Scott; Blaine Stine, W.; Shi, Pei‐Yong; E. Davis-Gardner, Meredith; S. Suthar, Mehul; Garcia-Knight, Miguel; Andino, Raul; Y. Chiu, Charles; H. Ellebedy, Ali; H. Fremont, Daved; P. J. Whelan, Sean; E. Crowe, James; A. Purcell, Lisa; Corti, Davide; C. M. Boon, Adrianus; Diamond, Michael

doi:10.1038/s41586-021-03720-y

Public

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

Published in Nature • Jun 21, 2021

Authors:

Rita E. Chen

Emma S. Winkler

James Brett Case

Abstract

Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures. Although cell culture experiments have demonstrated a loss of potency of several anti-spike neutralizing antibodies against variant strains of SARS-CoV-21–3, the in vivo importance of these results remains uncertain. Her...

Subject

Monoclonal antibody

Virology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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