Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

A. Collier, Dami; A.T.M. Ferreira, Isabella; Kotagiri, Prasanti; Datir, Rawlings; Y. Lim, Eleanor; Touizer, Emma; Meng, Bo; Abdullahi, Adam; Investigators, Principal; Baker, Stephen; Dougan, Gordon; Hess, Christoph; Kingston, Nathalie; J. Lehner, Paul; A. Lyons, Paul; J. Matheson, Nicholas; H. Owehand, Willem; Saunders, Caroline; Summers, Charlotte; Thaventhiran, James; Toshner, Mark; P. Weekes, Michael; H. Maxwell, Patrick; Shaw, Ashley; Bucke, Ashlea; Calder, Jo; Canna, Laura; Domingo, Jason; Elmer, Anne; Fuller, Stewart; Harris, Julie; Hewitt, Sarah; Kennet, Jane; Jose, Sherly; Kourampa, Jenny; Meadows, Anne; O’Brien, Criona; Price, Jane; Publico, Cherry; Rastall, Rebecca; M. S. Ribeiro, Carla; Rowlands, Jane; Ruffolo, Valentina; Tordesillas, Hugo; Logistics, Sample; Bullman, Ben; J. Dunmore, Benjamin; Fawke, Stuart; Ting Graf, Stefan; Hodgson, Josh; Huang, Christopher; Hunter, Kelvin; Jones, Emma; Legchenko, Ekaterina; Matara, Cecilia; Martin, Jennifer; Mescia, Federica; O’Donnell, Ciara; Pointon, Linda; Pond, Nicole; Shih, Joy; Sutcliffe, Rachel; Tilly, Tobias; Treacy, Carmen; Tong, Zhen; Wood, Jennifer; Wylot, Marta; Processing and Data Acquisition, Sample; Bergamaschi, Laura; Betancourt, Ariana; Bower, Georgie; Cossetti, Chiara; De, Aloka; Epping, Madeline; Fawke, Stuart; Gleadall, Nick; Grenfell, Richard; Hinch, Andrew; Huhn, Oisín; Jackson, Sarah; Jarvis, Isobel; A. Krishna, Benjamin; J. Lewis, D.; Marsden, Joe; Nice, Francesca; Okecha, Georgina; Omarjee, Ommar; Perera, Marianne; Potts, Martin; Richoz, Nathan; Romashova, Veronika; Savinykh Yarkoni, Natalia; Sharma, Rahul; Stefanucci, Luca; Stephens, Jonathan; Strezlecki, Mateusz; Turner, Lori; M. D. D. De Bie, Eckart; Bunclark, Katherine; Josipović, Maša; Mackay, Michael; Michael, Alice; Rossi, Sabrina; Selvan, Mayurun; Spencer, Sarah; Yong, Cissy; Ansaripour, Ali; Michael, Alice; Mwaura, Lucy; Patterson, Caroline; Polwarth, Gary; Polgarova, Petra; Di Stefano, Giovanni; Fahey, Codie; Michel, Rachel; Bong, Sze-How; D. Coudert, Jérôme; Holmes, Elaine; BioResource4, NIHR; Allison, John; Butcher, Helen; Caputo, Daniela; Clapham-Riley, Debbie; Dewhurst, Eleanor; Furlong, Anita; Graves, Barbara; Gray, Jennifer; Ivers, Tasmin; Kasanicki, Mary; Le Gresley, Emma; Linger, Rachel; Meloy, Sarah; Muldoon, Francesca; Ovington, Nigel; Papadia, Sofia; Phelan, Isabel; Stark, Hannah; Stirrups, Kathleen; Townsend, Paul; Walker, Neil; Webster, Jennifer; Elmer, Anne; Kingston, Nathalie; Graves, Barbara; Le Gresley, Emma; Caputo, Daniela; Bergamaschi, Laura; G. C. Smith, Kenneth; R. Bradley, John; Ceron‐Gutierrez, Lourdes; Cortes-Acevedo, Paulina; Barcenas‐Morales, Gabriela; A. Linterman, Michelle; E. McCoy, Laura; Davis, Christopher; C. Thomson, Emma; A. Lyons, Paul; McKinney, Eoin; Döffinger, Rainer; R. Wills, Mark; K. Gupta, Ravindra

doi:10.1038/s41586-021-03739-1

Public

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Published in Nature • Jun 30, 2021

Authors:

Dami A. Collier

Isabella A.T.M. Ferreira

Prasanti Kotagiri

Abstract

Abstract Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age 1 . Here we analysed immune responses following vaccination with the BNT162b2 mR...

Subject

Neutralization

Medicine

Vaccination

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