Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.

L, Rocheleau; G, Laroche; K, Fu; CM, Stewart; AO, Mohamud; M, Côté; PM, Giguère; MA, Langlois; M, Pelchat

doi:10.1128/mbio.00788-21

Public

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.

Shared by NobleBlocks on Jun 29, 2021 • 12:00 AM UTC

Authors:

Rocheleau L

Laroche G

Fu K

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that is continuously evolving. Although its RNA-dependent RNA polymerase exhibits some exonuclease proofreading activity, viral sequence diversity can be produced by replication errors and host factors. A diversity of geneti...

Subject

Spike protein

High-throughput Sequencing

Genetic Variants

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