Lung Ablation with Irreversible Electroporation Promotes Immune Cell Infiltration by Sparing Extracellular Matrix Proteins and Vasculature: Implications for Immunotherapy

Fujimori, Masashi; Kimura, Yasushi; Ueshima, Eisuke; E. Dupuy, Damian; S. Adusumilli, Prasad; B. Solomon, Stephen; Srimathveeravalli, Govindarajan

doi:10.1089/bioe.2021.0014

Public

Lung Ablation with Irreversible Electroporation Promotes Immune Cell Infiltration by Sparing Extracellular Matrix Proteins and Vasculature: Implications for Immunotherapy

Published in Bioelectricity • Jun 30, 2021

Authors:

Masashi Fujimori

Yasushi Kimura

Eisuke Ueshima

Abstract

Background: This study investigated the sparing of the extracellular matrix (ECM) and blood vessels at the site of lung irreversible electroporation (IRE), and its impact on postablation T cell and macrophage populations. Materials and Methods: Normal swine ( n = 8) lung was treated with either IRE ...

Subject

Decorin

Extracellular matrix

Pathology

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