DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Du, Jing; Wang, Xu; Li, Yanchun; Ren, Xueying; Zhou, Yi; Zhou, Yi; Hu, Wanye; Zhou, Chaoting; Jing, Qiangan; Yang, Chen; Wang, Luyang; Li, Huanjuan; Fang, Lijuan; Zhou, Yonglie; Zhou, Yonglie; Tong, Xiangmin; Wang, Ying

doi:10.1038/s41419-021-03996-y

Public

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Published in Cell Death and Disease • Jul 15, 2021

Authors:

Jing Du

Xu Wang

Yanchun Li

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer with limited treatment options. Cisplatin (DDP) is used as a mainstay of chemotherapeutic agents in combination with other drugs or radiotherapy for PDAC therapy. However, DDP exhibits severe side-effects that can lead to disconti...

Subject

Cancer research

Cisplatin

Apoptosis

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