Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Hou, Kai; Shen, Jianliang; Yan, Junrong; Zhai, Chuannan; Zhang, Jingxia; Pan, Ji-An; Zhang, Ye; Jiang, Yaping; Wang, Yongbo; Z. Lin, Richard; Cong, Hongliang; Gao, Shenglan; Zong, Wei‐Xing

doi:10.1016/j.ebiom.2021.103456

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Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Published in EBioMedicine • Jul 1, 2021

Authors:

Kai Hou

Jianliang Shen

Junrong Yan

Abstract

BACKGROUND: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that the ubiquitin E3 ligase TRIM21 in...

Subject

Doxorubicin

Cardiotoxicity

Cancer research

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