Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Hu, Tuo; K. Shukla, Surendra; Vernucci, Enza; He, Chunbo; Wang, Dezhen; J. King, Ryan; Jha, Kanupriya; Siddhanta, Kasturi; J. Mullen, Nicholas; S. Attri, Kuldeep; Murthy, Divya; V. Chaika, Nina; Thakur, Ravi; E. Mulder, Scott; G. Pacheco, Camila; Fu, Xiao; High, Robin; Yu, Fang; J. Lazenby, Audrey; Steegborn, Clemens; Lan, Ping; Mehla, Kamiya; Rotili, Dante; Chaudhary, Sarika; Valente, Sérgio; Tafani, Marco; Mai, Antonello; Auwerx, Johan; Verdin, Eric; A. Tuveson, David; K. Singh, Pankaj

doi:10.1053/j.gastro.2021.06.045

Public

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Published in Gastroenterology • Jul 8, 2021

Authors:

Tuo Hu

Surendra K. Shukla

Enza Vernucci

Abstract

BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) remains unknown. METHODS: Published da...

Subject

KRAS

Pancreatic cancer

Cancer research

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