SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

Lavigne, Marc; Helynck, Olivier; Rigolet, Pascal; Boudria-Souilah, Rofia; Nowakowski, Mireille; Baron, Bruno; Brûlé, Sébastien; Hoos, Sylviane; Raynal, Bertrand; Guittat, Lionel; Beauvineau, Claire; Pêtres, Stéphane; Granzhan, Anton; Guillon, Jean; Pratviel, Geneviève; Teulade‐Fichou, Marie‐Paule; England, Patrick; Mergny, Jean‐Louis; Munier‐Lehmann, Hélène

doi:10.1093/nar/gkab571

Public

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

Published in Nucleic Acids Research • Jun 19, 2021

Authors:

Marc Lavigne

Olivier Helynck

Pascal Rigolet

Abstract

The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by coronavirus (CoV) genomes and several regions of this protein are essential for viral replication. Of note, SARS-CoV Nsp3 contains a SARS-Unique Domain (SUD), which can bind Guanine-rich non-canonical nucleic acid stru...

Subject

Biology

Nucleic acid

Oligonucleotide

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