Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

Peng, Xin; Zhang, Shaolu; Jiao, Wenhui; Zhong, Zhenxing; Yang, Yuqi; X. Claret, François; Elkabets, Moshe; Wang, Feng; Wang, Ran; Zhong, Yuxu; Chen, Zhe‐Sheng; Kong, Dexin

doi:10.1186/s13046-021-02176-2

Public

Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

Published in Journal of Experimental & Clinical Cancer Research • Nov 29, 2021

Authors:

Xin Peng

Shaolu Zhang

Wenhui Jiao

Abstract

BACKGROUND: The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical trials have shown only a modest therapeutic efficacy of single-agent PI3Kis in...

Subject

Autophagy

ATG5

PI3K/AKT/mTOR pathway

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