Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, The; Domingo, Pere; Mur, Isabel; Mateo, Gràcia; del Mar Gutiérrez, María; Pomar, Virginia; Benito, Natividad; Corbacho, Noemí; Herrera, Silvia; F Pascual Millán, L; Muñoz, Jessica; Malouf, Jorge; Ema Molas, Maria; Asensi, Víctor; Pablo Horcajada, Juan; Estrada, Vicente; Gutiérrez, Félix; Torres, Ferràn; A. Pérez‐Molina, José; Fortün, Jesús; María Villar, Luisa; Hohenthal, Ulla; Marttila, Harri; Vuorinen, Tytti; Nordberg, Marika; Valtonen, Mika; J. Frigault, Matthew; K. Mansour, Michael; J. Patel, Naomi; D. Fernandes, Ana; Harvey, Liam; S. Foulkes, Andrea; C. Healy, Brian; Shah, Ruta; Maria Bensaci, Ana; E. Woolley, Ann; Nikiforow, Sarah; Lin, Nina; Sagar, Manish; Shrager, Harry; S. Huckins, David; Axelrod, Matthew; Pincus, Michael; Fleisher, Jorge; Lampa, Jon; Nowak, Piotr; Vesterbacka, Jan; Rasmuson, Johan; Skorup, Paul; Janols, Helena; Niward, Katarina; Chatzidionysiou, Katerina; Ásgeirsson, Hilmir; Parke, Åsa; Blennow, Ola; Svensson, Anna‐Karin; Aleman, Soo; Sönnerborg, Anders; Henter, Jan‐Inge; Horne, AnnaCarin; Al-Beidh, Farah; C. Angus, Derek; Annane, Djillali; M. Arabi, Yaseen; Beane, Abi; Berry, Scott; Bhimani, Zahra; J. M. Bonten, Marc; Bradbury, Charlotte; Brunkhorst, Frank; Buxton, Meredith; Cheng, Allen; Cove, Matt; D. de Jong, Menno; Derde, Lennie; J Estcourt, Lise; Goossens, Herman; Gordon, Anthony; Green, Cameron; Haniffa, Rashan; Ichihara, Nao; Lamontagne, François; R. Lawler, Patrick; Litton, Edward; Marshall, John; McArthur, Colin; F. McAuley, Daniel; McGuinness, Shay; J. McVerry, Bryan; Montgommery, Stephanie; Mouncey, Paul; Murthy, Srinivas; Nichol, Alistair; Parke, Rachael; Parke, Rachael; Reyes, Felipe; Rowan, Kathryn; Saito, Hiroki; Santos, Marlene; Seymour, Chris; Shankar‐Hari, Manu; F. Turgeon, Alexis; Turner, Anne; van Bentum-Puijk, Wilma; L. van de Veerdonk, Frank; Webb, Steve; Zarychanski, Ryan; Kenneth Baillie, J.; Beasley, Richard; Cooper, Nichola; Fowler, Robert; Galea, James; Hills, Thomas; J. King, Andrew; C. Morpeth, Susan; G. Netea, Mihai; Ogungbenro, Kayode; Pettilä, Ville; Y. C. Tong, Steven; Uyeki, Tim; Youngstein, Taryn; M. Higgins, Alisa; Lorenzi, Elizabeth; R. Berry, Lindsay; Salama, Carlos; O. Rosas, Iván; Ruíz‐Antorán, Belén; Múñez, Elena; Ramos, António; Campos Esteban, J.; Avendaño, C.; Pizov, Reuven; Sanz, Jesús; Abad‐Santos, Francisco; Bautista, Azucena; García‐Fraile, Lucio; Barrios, Ana; Gutiérrez, Ángela; Alonso, Tamara; C. Rodriguez-García, S.; Mejía‐Abril, Gina; Carlos Prieto, Jose; León, Rafael; Cordeiro Veiga, Viviane; Scheinberg, Phillip; Leão Cordeiro de Farias, Danielle; Antônio Gonçalves Garreta Prats, João; Biasi Cavalcanti, Alexandre; Machado, F.S.; Goulart Rosa, Régis; Berwanger, Otávio; César Pontes Azevedo, Luciano; D. Lópes, Renato; K. Dourado, Letícia; Galvão de Castro, Cláudio; G Zampieri, Fernando; Avezum, Álvaro; Lisboa, Thiago; Soriano Ordinola Rojas, Salomón; Chaves Coelho, Juliana; Thot Leite, Rodrigo; César de Carvalho, Júlio; Eduardo Coelho Andrade, Luís; R. SANDES, ALEX; Carolina Tostes Pintão, Maria; Vieira dos Santos, Sueli; Miranda Lopes de Almeida, Thiago; Nathan Costa, André; Gebara, Otávio; Geraldo Rezende de Freitas, Flávio; Souza Pacheco, Eduardo; Machado, David; Martin, Josiane; G. CONCEIÇÃO, FABIO; Rodrigues Rangel Siqueira, Suellen; Petri Damiani, Lucas; Morita Ishihara, Luciana; Schneider, Daniel; de Souza, Denise; Hermine, Olivier; Mariette, Xavier; Tharaux, Pierre‐Louis; Resche‐Rigon, Matthieu; Porcher, Raphael; Ravaud, Philippe; Azoulay, Élie; Cadranel, Jacques; Emmerich, Joseph; Fartoukh, Muriel; Guidet, Bertrand; Humbert, Marc; Lacombe, Karine; Mahévas, Matthieu; Pène, Frédéric; Pourchet-Martinez, Valérie; Schlemmer, F.; Tibi, Annick; Yazdanpanah, Yazdan; Dougados, Maxime; Bureau, Serge; Horby, Peter; Landray, Martin; Kenneth Baillie, J.; H Buch, Maya; C. Chappell, Lucy; Day, Jeremy; N. Faust, Saul; Haynes, Richard; Jaki, Thomas; Jeffery, Katie; Juszczak, Edmund; Shen Lim, Wei; Mafham, Marion; Montgomery, Alan; Mumford, Andrew; Thwaites, Guy; Kamarulzaman, Adeeba; Faridah Syed Omar, Sharifah; Ponnampalavanar, Sasheela; Iskandar Syah Raja Azwa, Raja; Li Wong, Pui; Kukreja, Anjanna; Cheng Ong, Hang; Sulaiman, Helmi; Basri, Sazali; Xiang Ng, Rong; Megat Johari, Bushra; Rajasuriar, Reena; Li Chong, Meng; Neelamegam, Malinee; Mukhtar Syed Mansor, Syed; Syuhada Zulhaimi, Nurul; Siang Lee, Cheng; L. Altice, Frederick; Price, Christina; Malinis, Maricar; Shahnaz Hasan, Mohd; K. Wong, C.; Kumar Chidambaram, Suresh; Arisah Misnan, Nor; Adlan Mohd Thabit, Alif; Lim Heng Sim, Benedict; Nadiah Bidin, Farah; Abd Hafiz Mohd Abd Rahim, Mohd; Saravanamuttu, Sujana; Xuan Tuang, Wei; Gani, Yasmin; Thangavelu, Suvintheran; Heng Tay, Kim; Munirah Ibrahim, Nur; Alhakim Halid, Luqman; Tong Tan, Kok; Noor Azreet Mukri, Mohd; Arip, Masita; Moon Koh, Hui; Nurul Ain Syed Badaruddin, Syarifah; Raja Sureja, Letchumi; Ying Chun, Geok; Torre‐Cisneros, Julián; Merchante, Nicolás; León, Rafael; Cárcel, Sheila; C. Garrido, José; Galun, E.; Soriano, Àlex; Antonio Martínez, José; Castán, Clara; Paredes, Roger; Dalmau, David; Carbonell, Cristina; Espinosa, Gerard; Castro, Pedro; Muñóz, José; Almuedo-Riera, Alex; Prieto, Sergio; Pacheco, Iván; J. Ratain, Mark; Pisano, Jennifer; E. Strek, Mary; Adegunsoye, Ayodeji; Karrison, Theodore; Declercq, Jozefien; Van Damme, Karel; Leeuw Elisabeth, De; Bosteels, Cédric; Maes, Bastiaan; Shankar‐Hari, Manu; L. Vale, Claire; J. Godolphin, Peter; J. Fisher, David; P. T. Higgins, Julian; Spiga, Francesca; Savović, Jelena; F. Tierney, Jayne; Baron, Gabriel; Benbenishty, Julie; R. Berry, Lindsay; Broman, Niklas; Biasi Cavalcanti, Alexandre; Colman, Roos; De Buyser, Stefanie; Derde, Lennie; Domingo, Pere; Faridah Syed Omar, Sharifah; Fernández‐Cruz, Ana; Feuth, Thijs; García, Felipe; García‐Vicuña, Rosario; González‐Álvaro, Isidoro; Gordon, Anthony; Haynes, Richard; Hermine, Olivier; Horby, Peter; Horick, Nora; Kumar, Kuldeep; N. Lambrecht, Bart; Landray, Martin; Leal, Lorna; J. Lederer, David; Lorenzi, Elizabeth; Mariette, Xavier; Merchante, Nicolás; Arisah Misnan, Nor; Mohan, Shalini; C. Nivens, Michael; Oksi, Jarmo; A. Pérez‐Molina, José; Pizov, Reuven; Porcher, Raphael; Postma, Simone; Rajasuriar, Reena; V Ramanan, Athimalaipet; Ravaud, Philippe; Reid, Pankti; Rutgers, Abraham; Sancho‐López, Aránzazu; B. Seto, Todd; Sivapalasingam, Sumathi; S. Soin, Arvinder; Staplin, Natalie; H. Stone, John; W. Strohbehn, Garth; Sundén‐Cullberg, Jonas; Torre‐Cisneros, Julián; Tsai, Larry; van Hoogstraten, Hubert; van Meerten, Tom; Cordeiro Veiga, Viviane; E. Westerweel, Peter; Murthy, Srinivas; Dı́az, Janet; C. Marshall, John; A C Sterne, Jonathan

doi:10.1001/jama.2021.11330

Public

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19

Published in JAMA • Jul 6, 2021

Authors:

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group

Pere Domingo

Isabel Mur

Abstract

Importance: Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm. Objective: To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-caus...

Subject

Medicine

Coronavirus disease 2019 (COVID-19)

2019-20 coronavirus outbreak

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