Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury

A. Redd, Meredith; Scheuer, S.; J. Saez, Natalie; Yoshikawa, Yusuke; Sheng Chiu, Han; Gao, Ling; Hicks, Mark; E. Villanueva, Jeanette; Joshi, Yashutosh; Yuen Chow, Chun; Cuéllar-Partida, Gabriel; N. Peart, Jason; E. See Hoe, Louise; Chen, Xiaoli; Sun, Yuliangzi; Y. Suen, Jacky; J. Hatch, Robert; Rollo, Ben; Xia, Di; A. Alzubaidi, Mubarak; Maljevic, Snezana; A. Quaife-Ryan, Gregory; E. Hudson, James; R. Porrello, Enzo; Y. White, Melanie; J. Cordwell, Stuart; F. Fraser, John; Petrou, Steven; E. Reichelt, Melissa; G. Thomas, Walter; F. King, Glenn; S. Macdonald, Peter; J. Palpant, Nathan

doi:10.1161/circulationaha.121.054360

Public

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury

Published in Circulation • Jul 15, 2021

Authors:

Meredith A. Redd

S. Scheuer

Natalie J. Saez

Abstract

BACKGROUND: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased intracellular and extracellular pH, which can reach as low as 6...

Subject

Medicine

Ex vivo

Cardioprotection

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