Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis

Yuan, Renyikun; Zhao, Wentong; Wang, Qinqin; He, Jia; Han, Shan; Gao, Hongwei; Feng, Yulin; Yang, Shilin

doi:10.1016/j.phrs.2021.105748

Public

Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis

Published in Pharmacological Research • Jul 1, 2021

Authors:

Renyikun Yuan

Wentong Zhao

Qinqin Wang

Abstract

Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted from muskmelon pedicel, is a natural bioactive product that could effectively exert anti-tumor activities in lung cancer....

Subject

Pyroptosis

Chemistry

In vivo

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