Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

H. Stokes, Barbara; K. Dhingra, Satish; Rubiano, Kelly; Mok, Sachel; Straimer, Judith; F. Gnädig, Nina; Deni, Ioanna; A. Schindler, Kyra; Bath, Jade; E. Ward, Kurt; Striepen, Josefine; Yeo, Tomas; S. Ross, Leila; Legrand, Eric; Ariey, Frédéric; H. Cunningham, Clark; Mahamat Souleymane, Issa; Gansané, Adama; Nzoumbou‐Boko, Romaric; Ndayikunda, Claudette; M. Kabanywanyi, Abdunoor; Uwimana, Aline; J. Smith, Samuel; Kolley, Olimatou; Ndounga, Mathieu; Warsame, Marian; Leang, Rithea; Nosten, François; J. C. Anderson, Timothy; J. Rosenthal, Philip; Ménard, Didier; A. Fidock, David

doi:10.7554/elife.66277

Public

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Published in eLife • Jul 19, 2021

Authors:

Barbara H. Stokes

Satish K. Dhingra

Kelly Rubiano

Abstract

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13- propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domin...

Subject

Plasmodium falciparum

Artemisinin

Malaria

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