hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

Jun Cai, Xiu; Zhang, Zhiyu; Yuan, Jintao; Kofi Wiredu Ocansey, Dickson; Tu, Qiang; Zhang, Xu; Qian, Hui; Xu, Wenrong; Qiu, Wei; Mao, Fei

doi:10.1186/s13287-021-02492-6

Public

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

Published in Stem Cell Research & Therapy • Jul 22, 2021

Authors:

Xiu Jun Cai

Zhiyu Zhang

Jintao Yuan

Abstract

BACKGROUND: Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal mucosal immunity. In this event, macrophage pyroptosis, a process of cell death fo...

Subject

Pyroptosis

Microvesicles

Inflammasome

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