Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Tonnus, Wulf; Meyer, Claudia; Steinebach, Christian; Belavgeni, Alexia; von Mäßenhausen, Anne; Zamora Gonzalez, Nadia; Maremonti, Francesca; Gembardt, Florian; Himmerkus, Nina; Latk, Markus; Locke, Sophie; A. Marschner, Julian; Li, Wenjun; Short, Spencer; Doll, Sebastian; Ingold, Irina; Proneth, Bettina; Daniel, Christoph; Kabgani, Nazanin; Kramann, Rafael; E. Motika, Stephen; J. Hergenrother, Paul; R. Bornstein, Stefan; Hugo, Christian; U. Becker, Jan; Amann, Kerstin; Anders, Hans‐Joachim; Kreisel, Daniel; A. Pratt, Derek; Gütschow, Michael; Conrad, Marcus; Linkermann, Andreas

doi:10.1038/s41467-021-24712-6

Public

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Published in Nature Communications • Jul 20, 2021

Authors:

Wulf Tonnus

Claudia Meyer

Christian Steinebach

Abstract

Abstract Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement of necroptosis is well characterized, genetic evidence supporting the contri...

Subject

Necroptosis

RIPK1

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