The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Avolio, Elisa; Carrabba, Michele; Milligan, Rachel; Kavanagh Williamson, Maia; P. Beltrami, Antonio; Gupta, Kapil; T. Elvers, Karen; Gamez, Monica; R. Foster, Rebecca; Gillespie, Kathleen; Hamilton, Fergus; Arnold, David; Berger, Imre; D. Davidson, Andrew; Hill, Darryl; Caputo, Massimo; Madeddu, Paolo

doi:10.1042/cs20210735

Public

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Published in Clinical Science • Nov 22, 2021

Authors:

Elisa Avolio

Michele Carrabba

Rachel Milligan

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range of clinical responses including prominent microvascular damage. The capacity of SARS-CoV-2 to infect vascular cells is still debated. Additionally, the SARS-CoV-2 Spike (S) protein may act as a ligand to induce non...

Subject

Cell biology

Receptor

Biology

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