Metformin in Combination With Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer

Tsakiridis, Theodoros; R. Pond, Gregory; Wright, Jim; M. Ellis, Peter; Ahmed, Naseer; Abdulkarim, Bassam; Roa, Wilson; Robinson, Andrew; Swaminath, Anand; Okawara, Gordon; Wierzbicki, Marcin; J. Valdés, Mario; N. Levine, Mark

doi:10.1001/jamaoncol.2021.2328

Public

Metformin in Combination With Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer

Published in JAMA Oncology • Jul 29, 2021

Authors:

Theodoros Tsakiridis

Gregory R. Pond

Jim Wright

Abstract

IMPORTANCE: Unresected locally advanced non-small cell lung cancer (LA-NSCLC) shows poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether metformin, a diabetes agent that inhibits the mitochondria oxidative phosphorylation chain, could improve radiotherapy and chemothera...

Subject

Medicine

Common Terminology Criteria for Adverse Events

Chemoradiotherapy

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