SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Pan, Pan; Shen, Miaomiao; Yu, Zhenyang; Ge, Weiwei; Chen, Keli; Tian, Mingfu; Xiao, Feng; Wang, Zhenwei; Wang, Jun; Jia, Yaling; Wang, Wenbiao; Wan, Pin; Zhang, Jing; Chen, Weijie; Lei, Zhiwei; Chen, Xin; Luo, Zhen; Zhang, Qiwei; Xu, Meng; Li, Geng; Li, Yongkui; Wu, Jianguo

doi:10.1038/s41467-021-25015-6

Public

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Published in Nature Communications • Aug 2, 2021

Authors:

Pan Pan

Miaomiao Shen

Zhenyang Yu

Abstract

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 ...

Subject

Inflammasome

Proinflammatory cytokine

Inflammation

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