Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer

Goffredo, Paolo; Khan, Adil; L. Mott, Sarah; C. Jensen, Christine; D. Madoff, Robert; B. Gaertner, Wolfgang; You, Yijie; Hassan, Imran

doi:10.1097/sla.0000000000005141

Public

Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer

Published in Annals of Surgery • Aug 4, 2021

Authors:

Paolo Goffredo

Adil Khan

Sarah L. Mott

Abstract

OBJECTIVE: To evaluate the impact of neoadjuvant multi-agent systemic chemotherapy and radiation (TNT) vs neoadjuvant single-agent chemoradiation (nCRT) and multi-agent adjuvant chemotherapy on overall survival (OS), tumor downstaging, and circumferential resection margin (CRM) status in patients wi...

Subject

Medicine

Neoadjuvant therapy

Colorectal cancer

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