Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Jiang, Shan; Shui, Yongjie; Cui, Yu; Tang, Chun; Wang, Xiaohua; Qiu, Xingyu; Hu, Weipeng; Fei, Lingyan; Li, Yun; Zhang, Suping; Zhao, Liang; Xu, Nan; Dong, Fang; Ren, Xiaoqiu; Liu, Ruisheng; B. Persson, Pontus; Patzak, Andreas; Yin Lai, En; Wei, Qichun; Zheng, Zhihua

doi:10.1016/j.redox.2021.102115

Public

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Published in Redox Biology • Aug 25, 2021

Authors:

Shan Jiang

Yongjie Shui

Yu Cui

Abstract

Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis. We test, whether TMAO augments angiotensin II (Ang II)-in...

Subject

Vasoconstriction

Angiotensin II

Endocrinology

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