Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

Wu, Yingcheng; Yang, Shuaixi; Ma, Jiaqiang; Chen, Zechuan; Song, Guohe; Rao, Dongning; Cheng, Yifei; Huang, Siyuan; Liu, Yifei; Jiang, Shan; Liu, Jinxia; Huang, Xiaowu; Wang, Xiaoying; Qiu, Shuangjian; Xu, Jianmin; Xi, Ruibin; Bai, Fan; Zhou, Jian; Fan, Jia; Zhang, Xiaoming; Gao, Qiang

doi:10.1158/2159-8290.cd-21-0316

Public

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

Published in Cancer Discovery • Aug 20, 2021

Authors:

Yingcheng Wu

Shuaixi Yang

Jiaqiang Ma

Abstract

Abstract Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 matched samples by using single-cell RNA sequencing and spatial transcriptomics. Strikingly, the metastatic microenvironment und...

Subject

Immune system

Colorectal cancer

Metastasis

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