Geranyl-geraniol addition affects potency of bisphosphonates—a comparison in vitro promising a therapeutic approach for bisphosphonate-associated osteonecrosis of the jaw and oral wound healing

Otto, Marius; Lux, Christine; Schlittenbauer, Tilo; Halling, Frank; Ziebart, Thomas

doi:10.1007/s10006-021-00982-8

Public

Geranyl-geraniol addition affects potency of bisphosphonates—a comparison in vitro promising a therapeutic approach for bisphosphonate-associated osteonecrosis of the jaw and oral wound healing

Published in Oral and Maxillofacial Surgery • Aug 15, 2021

Authors:

Marius Otto

Christine Lux

Tilo Schlittenbauer

Abstract

PURPOSE: Analysis of the influence of geranyl-geraniol (GG) addition on four bisphosphonate derivatives regarding their influence on cell viability and migration ability of bone metabolism and endothelial cells in vitro. METHODS: Clodronate, pamidronate, ibandronate, and zoledronate were observed wi...

Subject

Bisphosphonate

Medicine

Osteonecrosis of the jaw

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