Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

G. Boer, Cindy; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Zhang, Yanfei; Coutinho de Almeida, Rodrigo; Wu, Tian; Zheng, Jie; Hartley, April; Teder‐Laving, Maris; Heidi Skogholt, Anne; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Björnsdóttir, Gyða; E. Gabrielsen, Maiken; Gilly, Arthur; Ingvarsson, Þorvaldur; Bakke Johnsen, Marianne; Jónsson, Helgi; Kloppenburg, M.; Luetge, Almut; H. Lund, Sigrún; Mägi, Reedik; Mangino, Massimo; G. H. H. Nelissen, Rob; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; F. Thomas, Laurent; Tuerlings, Margo; Loughlin, John; Arden, Nigel; Birrell, Fraser; Carr, Andrew; Deloukas, Panos; Doherty, Michael; W. McCaskie, Andrew; Ollier, William; Rai, Ashok; H. Ralston, Stuart; D. Spector, Tim; A. Wallis, Gillian; E. Martinsen, Amy; J. Willer, Cristen; A. Fors, Egil; Mundal, Ingunn; Hagen, Knut; Bernhard Nilsen, Kristian; Udnesseter Lie, Marie; Børte, Sigrid; Brumpton, Ben; B. Nielsen, Jonas; G. Fritsche, Lars; Zhou, Wei; Heuch, Ingrid; Storheim, Kjersti; Tyrpenou, Evangelos; Koukakis, A.; Chytas, Dimitrios; Stergios Evangelopoulos, Dimitrios; Efstathios, Chronopoulos; G. Pneumaticos, Spiros; S. Nikolaou, Vasileios; Ν. Malizos, Κonstantinos; Anastasopoulou, Lydia; R. Abecasis, Gonçalo; Baras, Aris; Cantor, Michael; Coppola, Giovanni; Deubler, Andrew; N. Economides, Aris; A. Lotta, Luca; D. Overton, John; G. Reid, Jeffrey; R. Shuldiner, Alan; Karalis, Katia; Siminovitch, Katherine; Beechert, Christina; Forsythe, Caitlin; D. Fuller, Erin; Gu, Zhenhua; Lattari, Michael; Lopez, Alexander; D. Schleicher, Thomas; Sotiropoulos Padilla, Maria; Widom, Louis; E. Wolf, Sarah; Pradhan, Manasi; Manoochehri, Kia; Bai, Xiaodong; Balasubramanian, Suganthi; Boutkov, Boris; Eom, Gisu; Habegger, Lukas; Hawes, Alicia; Krasheninina, Olga; Lanche, Rouel; J. Mansfield, Adam; K. Maxwell, Evan; Nafde, Mona; O’Keeffe, Sean; Orelus, Max; Panea, Razvan; Polanco, Tommy; Rasool, Ayesha; Salerno, William; Staples, Jeffrey; Li, Dadong; Sharma, Deepika; Banerjee, Ilanjana; Bovijn, Jonas; E. Locke, Adam; Verweij, Niek; E. Haas, Mary; Hindy, George; De, Tanima; Akbari, Parsa; Sosina, Olukayode; A. R. Ferreira, Manuel; B. Jones, Marcus; Mighty, Jason; G. LeBlanc, Michelle; J. Mitnaul, Lyndon; C. Babis, George; Pui Yin Cheung, Jason; H. Kang, Jae; Kraft, Peter; A. Lietman, Steven; Samartzis, Dino; Eline Slagboom, P.; Stefansson, Kari; Þorsteinsdóttir, Unnur; H. Tobias, Jonathan; G. Uitterlinden, André; S. Winsvold, Bendik; Zwart, John‐Anker; Davey Smith, George; C. Sham, Pak; Þorleifsson, Guðmar; R. Gaunt, Tom; P. Morris, Andrew; M. Valdes, Ana; Tsezou, Aspasia; S.E. Cheah, Kathryn; Ikegawa, Shiro; Hveem, Kristian; Esko, Tõnu; Mark Wilkinson, J.; Meulenbelt, Ingrid; Ta Michael Lee, Ming; B. J. van Meurs, Joyce; Styrkársdóttir, Unnur; Zeggini, Eleftheria

doi:10.1016/j.cell.2021.07.038

Public

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Published in Cell • Aug 26, 2021

Authors:

Cindy G. Boer

Konstantinos Hatzikotoulas

Lorraine Southam

Abstract

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been ass...

Subject

Osteoarthritis

Biology

Disease

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!