Detection and characterization of lung cancer using cell-free DNA fragmentomes

Mathios, Dimitrios; Sidenius Johansen, Jakob; Cristiano, Stephen; E. Medina, Jamie; Phallen, Jillian; Richter Larsen, Klaus; C. Bruhm, Daniel; Niknafs, Noushin; Ferreira, Leonardo; Adleff, Vilmos; J. Chiao, Elaine; Leal, Alessandro; Noë, Michaël; R. White, James; S. Arun, Adith; Hruban, Carolyn; V. Annapragada, Akshaya; Østrup Jensen, Sarah; W. Ørntoft, Mai‐Britt; Husted Madsen, Anders; Carvalho, Beatriz; de Wit, Meike; Carey, Jacob; C. Dracopoli, Nicholas; Maddala, Tara; C. Fang, Kenneth; Hartman, Anne‐Renee; M. Forde, Patrick; Anagnostou, Valsamo; R. Brahmer, Julie; J.A. Fijneman, Remond; Jørgen Nielsen, Hans; A. Meijer, Gerrit; L. Andersen, Claus; Mellemgaard, Anders; E. Bojesen, Stig; B. Scharpf, Robert; E. Velculescu, Victor

doi:10.1038/s41467-021-24994-w

Public

Detection and characterization of lung cancer using cell-free DNA fragmentomes

Published in Nature Communications • Aug 20, 2021

Authors:

Dimitrios Mathios

Jakob Sidenius Johansen

Stephen Cristiano

Abstract

Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for...

Subject

Lung cancer

DNA

Computational biology

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