Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease

Yanai, Hidekatsu; Adachi, Hiroki; Hakoshima, Mariko; Katsuyama, Hisayuki

doi:10.3390/ijms22179221

Public

Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease

Published in International Journal of Molecular Sciences • Aug 26, 2021

Authors:

Hidekatsu Yanai

Hiroki Adachi

Mariko Hakoshima

Abstract

Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the end product of an exogenous purine from food and endogenously from damaged, dying, and dead cells. The kidney plays a dominant role in UA excretion, and the kidney excretes approximately 70% of daily produ...

Subject

Hyperuricemia

Kidney disease

Uric acid

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