Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Manry, Jérémy; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garçon, Pierre; G. Rivière, Jacques; Lagier, Jean-Christophe; Gentile, Stéphanie; B. Rosen, Lindsey; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Megarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; R. Heath, James; Luis Franco, José; Anaya, Juan-Manuel; Solé-Violán, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; M. Delmonte, Ottavia; Zhang, Yu; L. Snow, Andrew; M. Holland, Steven; M. Biggs, Catherine; Moncada-Vélez, Marcela; Augusto Arias, Andrés; Lorenzo, Lazaro; Boucherit, Soraya; Coulibaly, Boubacar; Anglicheau, Dany; M. Planas, Anna; Haerynck, Filomeen; Duvlis, Sotirija; L. Nussbaum, Robert; Ozcelik, Tayfun; Keles, Sevgi; A. Bousfiha, Ahmed; El Bakkouri, Jalila; Ramirez-Santana, Carolina; Paul, Stéphane; Pan-Hammarström, Qiang; Hammarström, Lennart; Dupont, Annabelle; Kurolap, Alina; N. Metz, Christine; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; A. Barreiros, Lucila; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; van de Beek, Diederik; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; G. Tangye, Stuart; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Y. Kann, Nelli; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Felipe Reyes, Luis; Chauvineau-Grenier, Angélique; Venet, Fabienne; Monneret, Guillaume; C. Nussenzweig, Michel; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; H. Dyer, Adam; P. Kennelly, Sean; M. Bourke, Nollaig; Halwani, Rabih; Saheb Sharif-Askari, Narjes; Dorgham, Karim; Sallette, Jérome; Mehlal Sedkaoui, Souad; AlKhater, Suzan; Rigo-Bonnin, Raúl; Morandeira, Francisco; Roussel, Lucie; C. Vinh, Donald; Rye Ostrowski, Sisse; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; N. Spaan, András; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; P. Lifton, Richard; Mane, Shrikant; Lab, HGID; Clinicians, COVID; Clinicians, COVID-STORM; Immune Response to COVID Group, NIAID; Study Group, NH-COVAIR; CHGE, Danish; Blood Donor Study, Danish; James’s Hospital SARS CoV2 Interest group, St.; COVID Cohort Study Group, French; COVID-Group, Imagine; Milieu Intérieur Consortium, The; Cohort, CoV-Contact; UMC Covid-19 Biobank Investigators, Amsterdam; Human Genetic Effort, COVID; cohort, CONSTANCES; Study, 3C-Dijon; HealthCare, Cerba; du Sang study group, Etablissement; S. Anderson, Mark; Boisson, Bertrand; Béziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Pärt; H. Mogensen, Trine; Rowen, Lee; Mond, James; Debette, Stéphanie; de Lamballerie, Xavier; Duval, Xavier; Mentré, France; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; K. Gregersen, Peter; Piemonti, Lorenzo; Rodríguez-Gallego, Carlos; D. Notarangelo, Luigi; C. Su, Helen; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; M. Rice, Charles; Tiberghien, Pierre; Zhang, Qian; Cobat, Aurélie; Abel, Laurent; Casanova, Jean-Laurent

doi:10.1126/sciimmunol.abl4340

Public

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Shared by NobleBlocks on Aug 10, 2021 • 12:00 AM UTC

Authors:

Paul Bastard

Adrian Gervais

Tom Le Voyer

Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutr...

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