Development of a model for fibroblast-led collective migration from breast cancer cell spheroids to study radiation effects on invasiveness

Jia, Mei; Böhland, Claudia; Geiger, Anika; Baur, Iris; Berner, Kristina; Heuer, Steffen; Liu, Xue; Mataite, Laura; Camila Melo-Narváez, M.; Özkaya, Erdem; Rupp, Anna; Siebenwirth, Christian; Thoma, Felix; F. Kling, Matthias; A. Friedl, Anna

doi:10.1186/s13014-021-01883-6

Public

Development of a model for fibroblast-led collective migration from breast cancer cell spheroids to study radiation effects on invasiveness

Published in Radiation Oncology • Aug 19, 2021

Authors:

Mei Jia

Claudia Böhland

Anika Geiger

Abstract

BACKGROUND: Invasiveness is a major factor contributing to metastasis of tumour cells. Given the broad variety and plasticity of invasion mechanisms, assessing potential metastasis-promoting effects of irradiation for specific mechanisms is important for further understanding of potential adverse ef...

Subject

Fibroblast

Spheroid

Extracellular matrix

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