The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

A. Porritt, Rebecca; Binek, Aleksandra; Paschold, Lisa; Noval Rivas, Magali; McArdle, Angela; M. Yonker, Lael; Alter, Galit; Chandnani, Harsha; Lopez, Merrick; Fasano, Alessio; E. Van Eyk, Jennifer; Binder, Mascha; Arditi, Moshe

doi:10.1172/jci151520

Public

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

Published in Journal of Clinical Investigation • Aug 26, 2021

Authors:

Rebecca A. Porritt

Aleksandra Binek

Lisa Paschold

Abstract

Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. Here, we utilized proteomics, RNA sequencing, autoantibody arrays, and B cell receptor (BCR) repertoire analysis...

Subject

Immunology

Autoantibody

Superantigen

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