N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Liu, Zhenchuan; Wang, Tingting; She, Yunlang; Wu, Kaiqing; Gu, Shaorui; Li, Lei; Dong, Chenglai; Chen, Chang; Zhou, Yongxin

doi:10.1186/s12943-021-01398-4

Public

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Published in Molecular Cancer • Aug 20, 2021

Authors:

Zhenchuan Liu

Tingting Wang

Yunlang She

Abstract

Abstract Background An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progression. However, much remains unknown regarding whether circRNAs impact...

Subject

Biology

Immune system

Downregulation and upregulation

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