SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues

Cai, Guoshuai; Du, Mulong; Bossé, Yohan; Albrecht, Helmut; Qin, Fei; Luo, Xizhi; Michelle Androulakis, X.; Cheng, Chao; Nagarkatti, Mitzi; Nagarkatti, Prakash; C. Christiani, David; L. Whitfield, Michael; I. Amos, Christopher; Xiao, Feifei

doi:10.3390/ijms22179228

Public

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues

Published in International Journal of Molecular Sciences • Aug 26, 2021

Authors:

Guoshuai Cai

Mulong Du

Yohan Bossé

Abstract

The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, ...

Subject

DC-SIGN

Downregulation and upregulation

Immunology

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