Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Liu, Wei; Liu, Wei; Xie, Lei; He, Yao-Hui; Wu, Zhi-Yong; Liu, Lu-Xin; Bai, Xuefeng; Deng, Dan-Xia; Xu, Xiu‐E; Liao, Lian-Di; Lin, Wan; Heng, Jing-Hua; Xu, Xin; Peng, Liu; Huang, Qingfeng; Li, Chengyu; Zhang, Zhi-Da; Wang, Wei; Zhang, Guo-Rui; Gao, Xiang; Wang, Shaohong; Li, Chun-Quan; Xu, Li-Yan; Liu, Wen; Liu, Wen; Li, En‐Min

doi:10.1038/s41467-021-25202-5

Public

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Published in Nature Communications • Aug 16, 2021

Authors:

Wei Liu

Lei Xie

Abstract

Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling of EC tumors and adj...

Subject

Phosphoproteomics

Proteomics

Computational biology

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