Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Zhang, Xiannian; Peng, Linna; Luo, Yingying; Zhang, Shaosen; Pu, Yang; Chen, Yamei; Guo, Wenjia; Yao, Jiacheng; Shao, Mingming; Fan, Wenyi; Cui, Qionghua; Xi, Yiyi; Sun, Yanxia; Niu, Xiangjie; Zhao, Xuan; Chen, Liping; Wang, Yuqian; Liu, Yachen; Yang, Xinyu; Wang, Chengcheng; Zhong, Ce; Tan, Wen; Wang, Jianbin; Wu, Chen; Lin, Dongxin

doi:10.1038/s41467-021-25539-x

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Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Published in Nature Communications • Sep 6, 2021

Authors:

Xiannian Zhang

Linna Peng

Yingying Luo

Abstract

Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the composition of ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 individuals. We identify 8 common expression p...

Subject

Transcriptome

Stromal cell

Cell

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