Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

Galetzka, Danuta; Boeck, Julia; Dittrich, Marcus; Sinizyn, Olesja; Ludwig, Marco; Rossmann, Heidi; Spix, Claudia; P. Radsak, Markus; Scholz-Kreisel, Peter; Mirsch, J.; Linke, Matthias; Brenner, Walburgis; Marron, Manuela; Poplawski, Alicia; Prawitt, Dirk; Haaf, Thomas; Schmidberger, Heinz

doi:10.21203/rs.3.rs-55470/v1

Public

Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

Published • Aug 12, 2020

Authors:

Danuta Galetzka

Julia Boeck

Marcus Dittrich

Abstract

Abstract Background: Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. This suggests other predisposition defects that may support the oncogenic transformation of cells, e.g. via impaired DNA-repair. Our study consequently aims to i...

Subject

Transformation (genetics)

Cancer research

Cancer

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