Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2

Deepak, Parakkal; Kim, Wooseob; Paley, Michael; Yang, Monica; Carvidi, Alexander; Demissie, Emanuel; A. El‐Qunni, Alia; Haile, Alem; Huang, Katherine; Kinnett, Baylee; J. Liebeskind, Mariel; Liu, Zhuoming; E. McMorrow, Lily; Paez, Diana; Pawar, Niti; C. Perantie, Dana; E. Schriefer, Rebecca; E. Sides, Shannon; Thapa, Mahima; Gergely, M; Abushamma, Suha; Akuse, Sewuese; K. Klebert, Michael; M. Mitchell, Lynne; Nix, Darren; Graf, Jonathan; E. Taylor, Kimberly; Chahin, Salim; A. Ciorba, Matthew; Katz, Patricia; Matloubian, Mehrdad; A. O’Halloran, Jane; M. Presti, Rachel; F. Wu, Gregory; P. J. Whelan, Sean; Buchser, William; S. Gensler, Lianne; C. Nakamura, Mary; H. Ellebedy, Ali; H.J. Kim, Alfred

doi:10.7326/m21-1757

Public

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2

Published in Annals of Internal Medicine • Aug 30, 2021

Authors:

Parakkal Deepak

Wooseob Kim

Michael Paley

Abstract

BACKGROUND: Patients with chronic inflammatory disease (CID) treated with immunosuppressive medications have increased risk for severe COVID-19. Although mRNA-based SARS-CoV-2 vaccination provides protection in immunocompetent persons, immunogenicity in immunosuppressed patients with CID is unclear....

Subject

Medicine

Immunogenicity

Vaccination

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