A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

P. Wightman, Douglas; E. Jansen, Iris; E. Savage, Jeanne; Shadrin, Alexey; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; S. Winsvold, Bendik; Kristian Drange, Ole; E. Martinsen, Amy; Heidi Skogholt, Anne; J. Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; B. Nielsen, Jonas; G. Fritsche, Lars; F. Thomas, Laurent; M. Pedersen, Linda; E. Gabrielsen, Maiken; Bakke Johnsen, Marianne; Wergeland Meisingset, Tore; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Heilbron, Karl; Auton, Adam; Agee, Michelle; Aslibekyan, Stella; Babalola, Elizabeth; K. Bell, Robert; Bielenberg, Jessica; Bryc, Katarzyna; Bullis, Emily; Cameron, Briana; Coker, Daniella; Cuéllar-Partida, Gabriel; Dhamija, Devika; Das, Sayantan; L. Elson, Sarah; Filshtein, Teresa; Fletez‐Brant, Kipper; Fontanillas, Pierre; Freyman, Will; Gandhi, Pooja; Hicks, Barry; A. Hinds, David; E. Huber, Karen; M. Jewett, Ethan; Jiang, Yunxuan; Kleinman, Aaron; Kukar, Katelyn; Lane, Vanessa; Lin, Keng‐Han; Lowe, Maya; K. Luff, Marie; C. McCreight, Jey; H. McIntyre, Matthew; F. McManus, Kimberly; J. Micheletti, Steven; E. Moreno, Meghan; L. Mountain, Joanna; V. Mozaffari, Sahar; Nandakumar, Priyanka; S. Noblin, Elizabeth; O’Connell, Jared; A. Petrakovitz, Aaron; David Poznik, G.; Schumacher, Morgan; J. Shastri, Anjali; F. Shelton, Janie; Shi, Jingchunzi; Shringarpure, Suyash; Tian, Chao; Tran, Vinh; Y. Tung, Joyce; Wang, Xin; Wang, Wei; H. Weldon, Catherine; Wilton, Peter; Sealock, Julia; K. Davis, Lea; L. Pedersen, Nancy; A. Reynolds, Chandra; Karlsson, Ida; H. Magnússon, Sigurður; Stefánsson, Hreinn; Þórðardóttir, Steinunn; V. Jónsson, Pálmi; Snædal, Jón; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Wærn, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John‐Anker; Athanasiu, Lavinia; Selnes, Per; Saltvedt, Ingvild; Botne Sando, Sigrid; Ulstein, Ingun; Djurovic, Srdjan; Fladby, Tormod; Aarsland, Dag; Selbæk, Geir; Ripke, Stephan; Stefánsson, Kāri; A. Andreassen, Ole; Posthuma, Daniëlle

doi:10.1038/s41588-021-00921-z

Public

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Published in Nature Genetics • Sep 1, 2021

Authors:

Douglas P. Wightman

Iris E. Jansen

Jeanne E. Savage

Abstract

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven pre...

Subject

Biology

Disease

Genome-wide association study

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