Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer

Bortolini Silveira, Amanda; Bidard, François‐Clément; Tanguy, Marie‐Laure; Girard, Elodie; Trédan, Olivier; Dubot, Coraline; Jacot, William; Gonçalvès, Anthony; Debled, Marc; Lévy, Christelle; Ferrero, Jean-­Marc; Jouannaud, Christelle; Rios, María; Mouret‐Reynier, Marie‐Ange; Dalenc, Florence; Hego, Caroline; Rampanou, Aurore; Albaud, Benoît; Baulande, Sylvain; Berger, Frédérique; Lemonnier, Jérôme; Renault, Shufang; Desmoulins, Isabelle; Proudhon, Charlotte; Pierga, Jean‐Yves

doi:10.1038/s41523-021-00319-4

Public

Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer

Published in npj Breast Cancer • Sep 9, 2021

Authors:

Amanda Bortolini Silveira

François‐Clément Bidard

Marie‐Laure Tanguy

Abstract

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are two cancer-derived blood biomarkers that inform on patient prognosis and treatment efficacy in breast cancer. We prospectively evaluated the clinical validity of quantifying both CTCs (CellSearch) and ctDNA (targeted next-generatio...

Subject

Medicine

Liquid biopsy

Internal medicine

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