Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Ren, Xueying; Li, Yanchun; Zhou, Yi; Hu, Wanye; Yang, Chen; Jing, Qiangan; Zhou, Chaoting; Wang, Xu; Hu, Jiayu; Wang, Luyang; Yang, Jing; Wang, Hairui; Xu, Haifeng; Li, Yanchun; Tong, Xiangmin; Wang, Ying; Du, Jing

doi:10.1016/j.redox.2021.102122

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Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Published in Redox Biology • Aug 31, 2021

Authors:

Xueying Ren

Yanchun Li

Yi Zhou

Abstract

Hepatocellular carcinoma (HCC) is one of the paramount causes of cancer-related death worldwide. Despite recent advances have been made in clinical treatments of HCC, the general prognosis of patients remains poor. Therefore, it is imperative to develop a less toxic and more effective therapeutic st...

Subject

Sorafenib

Disulfiram

Cancer research

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