Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

Xiang, Kun; Wang, Peng; Xu, Zhiwei; Hu, Yuqian; He, Yisheng; Chen, Yue; Feng, Ya-Ting; Yin, Kang-Jia; Huang, Ji-Xiang; Wang, Jie; Wu, Zhendong; Yang, Xiao‐Ke; Wang, De‐Guang; Ye, Dong‐Qing; Pan, Hai‐Feng

doi:10.3389/fimmu.2021.667097

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Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

Published in Frontiers in Immunology • Sep 7, 2021

Authors:

Kun Xiang

Peng Wang

Zhiwei Xu

Abstract

The observational association between gut microbiome and systemic lupus erythematosus (SLE) has been well documented. However, whether the association is causal remains unclear. The present study used publicly available genome-wide association study (GWAS) summary data to perform two-sample Mendelia...

Subject

Mendelian randomization

Genome-wide association study

Single-nucleotide polymorphism

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