Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade

Abstract TGF-β is secreted in the tumour microenvironment in a latent, inactive form bound to latency associated protein and activated by the integrin α V subunit. The activation of latent TGF-β by cancer-cell-expressed α V re-shapes the tumour microenvironment, and this could affect patient respons... View More