SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Mlčochová, Petra; A. Kemp, Steven; Shanker Dhar, Mahesh; Papa, Guido; Meng, Bo; A.T.M. Ferreira, Isabella; Datir, Rawlings; A. Collier, Dami; Albecka, Anna; Kumar Singh, Sujeet; Pandey, Rajesh; C. Brown, Jonathan; Zhou, Jie; Goonawardane, Niluka; Mishra, Swapnil; Whittaker, Charles; A. Mellan, Thomas; Marwal, Robin; Datta, Meena; Sengupta, Shantanu; Ponnusamy, Kalaiarasan; Radhakrishnan, Venkatraman; Abdullahi, Adam; Charles, Oscar; Chattopadhyay, Partha; Devi, Priti; Caputo, Daniela; Peacock, Tom; Wattal, Chand; Goel, Neeraj; Satwik, Ambrish; Vaishya, Raju; Agarwal, Meenakshi; Chauhan, Himanshu; Dikid, Tanzin; Gogia, Hema; Lall, Hemlata; Verma, Kaptan; Shanker Dhar, Mahesh; Kumar Singh, Manoj; Soni, Namita; Meena, Namonarayan; Madan, Preeti; Singh, Priyanka; Sharma, Ramesh; Sharma, Rajeev; Kabra, Sandhya; Kumar, Sattender; Kumari, Swati; Sharma, Uma; Chaudhary, Urmila; Sivasubbu, Sridhar; Scaria, Vinod; Kaur Oberoi, Jaspal; Raveendran, Reena; K. Datta, Sandip; Das, Saumitra; Maitra, Arindam; Chinnaswamy, Sreedhar; K. Biswas, Nidhan; Parida, Ajay; K. Raghav, Sunil; Prasad, Punit; Sarin, Apurva; Mayor, Satyajit; Ramakrishnan, Uma; Palakodeti, Dasaradhi; Sai Narain Seshasayee, Aswin; Thangaraj, Kumarasamy; Dharan Bashyam, Murali; Dalal, Ashwin; Kumar Bhat, Manoj; S. Shouche, Yogesh; D. Pillai, Ajay; Abraham, Priya; Potdar, Varsha; Cherian, Sarah; Desai, Anita; Pattabiraman, Chitra; V. Manjunatha, M.; S. Mani, Reeta; Arunachal Udupi, Gautam; Kumar Nandicoori, Vinay; Bharadwaj Tallapaka, Karthik; Tej Sowpati, Divya; Kawabata, Ryoko; Morizako, Nanami; Sadamasu, Kenji; Asakura, Hiroyuki; Nagashima, Mami; Yoshimura, Kazuhisa; Ito, Jumpei; Kimura, Izumi; Uriu, Keiya; Kosugi, Yusuke; Suganami, Mai; Oide, Akiko; Yokoyama, Miyabishara; Chiba, Mika; Saito, Akatsuki; P. Butlertanaka, Erika; Tanaka, Yuri; Ikeda, Terumasa; Motozono, Chihiro; Nasser, Hesham; Shimizu, Ryo; Yuan, Yue; Kitazato, Kazuko; Hasebe, Haruyo; Nakagawa, So; Wu, Jiaqi; Takahashi, Miyoko; Fukuhara, Takasuke; Shimizu, Kenta; Tsushima, Kana; Kubo, Haruko; Shirakawa, Kotaro; Kazuma, Yasuhiro; Nomura, Ryosuke; Horisawa, Yoshihito; Takaori‐Kondo, Akifumi; Tokunaga, Kenzo; Ozono, Seiya; Baker, Stephen; Dougan, Gordon; Hess, Christoph; Kingston, Nathalie; J. Lehner, Paul; Lyons, Paul; J. Matheson, Nicholas; H. Owehand, Willem; Saunders, Caroline; Summers, Charlotte; Thaventhiran, James; Toshner, Mark; P. Weekes, Michael; H. Maxwell, Patrick; Shaw, Ashley; Bucke, Ashlea; Calder, Jo; Canna, Laura; Domingo, Jason; Elmer, Anne; Fuller, Stewart; Harris, Julie; Hewitt, Sarah; Kennet, Jane; Jose, Sherly; Kourampa, Jenny; Meadows, Anne; O’Brien, Criona; Price, Jane; Publico, Cherry; Rastall, Rebecca; M. S. Ribeiro, Carla; Rowlands, Jane; Ruffolo, Valentina; Tordesillas, Hugo; Bullman, Ben; J. Dunmore, Benjamin; Fawke, Stuart; Ting Graf, Stefan; Hodgson, Josh; Huang, Christopher; Hunter, Kelvin; Jones, Emma; Legchenko, Ekaterina; Matara, Cecilia; Martin, Jennifer; Mescia, Federica; O’Donnell, Ciara; Pointon, Linda; Pond, Nicole; Shih, Joy; Sutcliffe, Rachel; Tilly, Tobias; Treacy, Carmen; Tong, Zhen; Wood, Jennifer; Wylot, Marta; Bergamaschi, Laura; Betancourt, Ariana; Bower, Georgie; Cossetti, Chiara; De, Aloka; Epping, Madeline; Fawke, Stuart; Gleadall, Nick; Grenfell, Richard; Hinch, Andrew; Huhn, Oisín; Jackson, Sarah; Jarvis, Isobel; A. Krishna, Benjamin; J. Lewis, Daniel; Marsden, Joe; Nice, Francesca; Okecha, Georgina; Omarjee, Ommar; Perera, Marianne; Potts, Martin; Richoz, Nathan; Romashova, Veronika; Savinykh Yarkoni, Natalia; Sharma, Rahul; Stefanucci, Luca; Stephens, Jonathan; Strezlecki, Mateusz; Turner, Lori; M. D. D. De Bie, Eckart; Bunclark, Katherine; Josipović, Maša; Mackay, Michael; Rossi, Sabrina; Selvan, Mayurun; Spencer, Sarah; Yong, Cissy; Allison, John; Butcher, Helen; Caputo, Daniela; Clapham-Riley, Debbie; Dewhurst, Eleanor; Furlong, Anita; Graves, Barbara; Gray, Jennifer; Ivers, Tasmin; Kasanicki, Mary; Le Gresley, Emma; Linger, Rachel; Meloy, Sarah; Muldoon, Francesca; Ovington, Nigel; Papadia, Sofia; Phelan, Isabel; Stark, Hannah; Stirrups, Kathleen; Townsend, Paul; Walker, Neil; Webster, Jennifer; Scholtes, Ingrid; Hein, Sabine; L. King, Rebecca; Mavousian, Antranik; Hyeon Lee, Joo; Bassi, Jessica; Silacci-Fegni, Chiara; Saliba, Christian; Pinto, Dora; Irie, Takashi; Yoshida, Isao; L. Hamilton, William; Sato, Kei; Bhatt, Samir; Flaxman, Seth; C. James, Leo; Corti, Davide; Piccoli, Luca; Barclay, William; Rakshit, Partha; Agrawal, Anurag; K. Gupta, Ravindra

doi:10.1038/s41586-021-03944-y

Public

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Published in Nature • Sep 6, 2021

Authors:

Petra Mlčochová

Steven A. Kemp

Mahesh Shanker Dhar

Abstract

. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in...

Subject

Evasion (ethics)

Virology

Replication (statistics)

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