Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure

J. McNamee, James; Gillies, Michael; Barrett, Nicholas; D. Perkins, Gavin; Tunnicliffe, William; Young, Duncan; Bentley, Andrew; A Harrison, David; Brodie, Daniel; Boyle, Andrew; Millar, Jonathan; Szakmány, Tamás; Bannard‐Smith, Jonathan; Tully, Redmond; Agus, Ashley; McDowell, Clíona; E. Jackson, Colette; F. McAuley, Daniel; Investigators, REST; Adedoyin, Temi; Adeniji, Kayode; Aherne, Caroline; Anand Iyer, Gopal; Andreou, Prematie; Andrew, Gillian; Angus, Ian; Arbane, Gill; Austin, Pauline; Austin, Karen; Auzinger, G.; Ball, Jonathan; Banach, Dorota; Bannard‐Smith, Jonathan; Bannon, Leona; Barclay, Lucy; Barcraft-Barnes, Helena; Beale, Richard; Bean, Sarah; Bentley, Andrew; Bercades, Georgia; Bergin, Colin; Bhardwaj, Sian; Bigham, Colin; Birkinshaw, Isobel; Black, Euan; Bociek, Aneta; Bodenham, Andrew; Booth, Malcolm; Bowyer, Christine; Brealey, David; J. Brett, Stephen; Brooks, J.G.; Burt, Karen; Cabrelli, Louise; Cabreros, Leilani; Cahill, Hazel; N Campbell, A; Camporota, Luigi; Campos, Sara; Camsooksai, Julie; Carrera, Ronald; W. S. Carter, J.; Carungcong, Jaime; Catelan-Zborowski, Anelise; Cathcart, Susanne; Champanerkar, Shreekant; Charlton, Matthew; Cherian, Shiney; Christie, Linsey; Chukkambotla, Srikanth; Clark, Amy; A. Clark, Sarah; A. Clark, Richard; Clement, Ian; Cocks, Eve; Cole, Stephen; Cole, Sonia; Cole, Jade; Coleman, Nick; Connaughton, Emma; Conway Morris, Andrew; B. Cooper, Lauren; A. Cooper, Ian; Corbett, Carolyn; Cornell, Sarah; Correia, Carmen; Cottam, V; Couper, Keith; Creighton, Laura; Crews, Maryam; Crooks, Neil; Curtin, Jacqueline; Daly, Zoe; Davidson, Alan; Davies, Rhys; Davies, Michelle; Day, Christopher; Dean, Mike; Dempsey, Ged; Dennis, Anna; Dermody, Susan; Despy, Liesl; Devaramani, Murugesh; Doble, Patricia; Docking, Robert; Donnelly, Adrian; Dooley, Natalie; Dormand, Natalie; Drummond, Andrew; Dunn, Mark; Dunn, Leigh; Eastgate, Christine; Ellis, Karen; Farnell, Sarah; Farrah, Helen; Fellows, Emma; Felton, Timothy; Filipe, Helder; Finney, Clare; J. Finney, Simon; Fitchett, Jillian; T. Gammon, Brian; Ganguly, Saibal; Gellamucho, Minerva; Gibson, Susan; L. GIBSON, CHARLES; Gilfeather, Lynn; Gillies, Michael; Gillon, Stuart; Gopal, Shameer; Gordon, Anthony; Goundry, Stephanie; Grainger, Lia; Grau Novellas, Neus; Gresty, Joanne; Griffiths, Mark; Gross, Jamie; Gunter, Una; Hallett, Karen; Harkett, Samantha; Harrison-Briggs, Donna; Hartley, Louise; Hass, Ingrid; Hemmings, Noel; Henderson, Steven; Hill, Helen; Hodkinson, Gemma; Howard, Kate; Howcroft, Clare; Hu, Ying; Hulme, Jonathan; Husain, Tariq; Hutter, Joanne; Ilano, Dorothy; Innes, Richard; Jacques, Nicola; Aissi James, Sarah; M. Jenkins, Sarah; Johnston, Paul; Johnston, Brian; Jones-Criddle, Colette; Kannan, Santhana; Bhuie, Parminder; Kelly, Andrea; Kennedy-Hay, Sophie; Lankester, Liana; Leaver, Susannah; Ledot, Stéphane; Lim, Rosario; Linhartová, Lucie; Long, Fei; MacCallum, Niall; MacGill, Sarah; Mackay, Andrew; MacLean, Sarah; Markham, Amber; Martín, Daniel; Martin, Tim; Mason, Tracy; Mason, Nick; McCann, Justine; McCulloch, Corrienne; McGhee, Christopher; McGinley-Keag, Loren; G. McLaughlin, Michael; McNamee, Lia; McNeil, Margaret; Mee, Laura; Mellis, Claire; Melody, Teresa; Mills, Jeanette; Molina, Esther; Morgan, Matt; Mpelembue, Mushiya; Muldoon, Stephanie; Munt, Sheila; Nordin, Nazril; Nutt, Christopher; O’Kane, Sinéad; O’Neill, Aisling; Page, Valérie; Paramasivam, Elankumaran; Parekh, Dhruv; Patch, Sarah; Patel, Sameer; Paton, Lia; D. Perkins, Gavin; Pinto, Manuel; Pogson, David; Polgarova, Petra; Singh Pooni, Jagtar; Pope, Martin; Price, Grant; Maria, Jashmin; Purdy, Lynda; Puxty, Alex; Rae, John; Raper, Mark; Reschreiter, Henrik; Rose, Steve; Rostron, Anthony; Roy, Alistair; Ryan, Christine; Hee Ryu, Jung; Salaunkey, Kiran; Sampson, Julia; Sathianathan, Vivian; Scaife, Lorraine; WM Scott, Simon; Scott, Timothy; Shanbhag, Sumant; M. Shaw, David; Sim, Malcolm; Singh, Suveer; Smallwood, Andrew; Smith, Hazel; Smith, John; Lawton Smith, J.; Smyth, Deborah; Snelson, Catherine; Z. Spivey, Michael; Spruce, Elaine; Summers, Charlotte; Sutton, Peter; Szakmány, Tamás; Talbot, Nicholas; Templeton, Maie; Thrush, Jessica; Tully, Redmond; Tunnicliffe, William; Turner-Bone, Ian; Veenith, Tonny; Vuylsteke, Alan; Walden, Andrew; Walker, Jonathan; Ward, Kathryn; Walsh, Timothy; Waugh, Victoria; Wells, Colin; Welters, Ingeborg; Whitehouse, Tony; Whitehouse, Arlo; Chris Whitton, R.; Wilby, Elizabeth; Wilcox, Danielle; Wilding, Laura; Williams, James; Williams, Karen; Winnard, Sarah; Woods, Lindsey; Wright, Chris; Young, Neil; Zhao, Xiaobei; Zolfaghari, Parjam

doi:10.1001/jama.2021.13374

Public

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure

Published in JAMA • Aug 31, 2021

Authors:

James J. McNamee

Michael Gillies

Nicholas Barrett

Abstract

Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine whether lower tidal volume mechanical ventilation using extra...

Subject

Medicine

Tidal volume

Mechanical ventilation

Research Assistant

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